Modifiers of the Efficacy of Risk-Reducing Salpingo-Oophorectomy for the Prevention of Breast and Ovarian Cancer in Carriers of BRCA1 and BRCA2
Abstract
The principle investigator was funded via a Physician-Scientist Training Award to participate in a comprehensive training plan to foster the transition to independent clinical breast cancer researcher. This plan included 1) conduct of a prospective study examining modifiers of the efficacy of risk-reducing salpingo-oophorectomy for the prevention of breast and ovarian cancer in carriers of BRCA mutations; and 2) participation in didactic coursework and structured training in research methodology, biostatistics, molecular biology, and ethics. Progress from 5/1/2005 - 4/30/2006 includes: 1) Presentation of the first prospective data able to examine the efficacy of risk-reducing salpingo-oophorectomy for the prevention of BRCA-associated breast and gynecologic cancer when BRCA1 and BRCA2 mutation carriers are examined separately; 2) Publication of the first prospective data examining the risk of breast and ovarian cancer in BRCA-negative hereditary breast cancer families; and 3) Publication of a robust method for testing for BRCA1 and BRCA2 founder mutations in formalin-fixed paraffin-embedded tissue; 4) Continuation of formal training in genetic epidemiology laboratory methods, outcomes analysis, and conduct of clinical research; and 5) Receipt of an R03 award (1 R03 CA119265-01 to N.D.K.) to conduct a genetic epidemiologic, computational and structural analysis of BRCA2 variants of uncertain significance.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2006
- Accession Number
- ADA457472
Entities
People
- Noah D. Kauff
Organizations
- Memorial Sloan Kettering Cancer Center