The Pathogenesis and Therapy of Combined Radiation Injury

Abstract

Cytokine production by different kinds of macrophages, and serum IL-1Beta, TNF-alpha, IL-6, IL-3, and GM-CSF levels, were evaluated in a murine model of combined injury (whole body irradiation + thermal burn). The results were compared with systemic cytokine responses to radiation or burn alone. The obtained data suggest that increased IL-6 levels may play an important role in the pathogenesis of combined injury. Single injection of extract from Serratia marcescens (Imuvert) or synthetic trehalose dicorynomy-colate improved hematological status, enhanced the serum IL-6 levels, but did not promote survival in mice. On the other hand, heat-killed Lactobacillus acidophilus demonstrated a weak effect on cytokine response, did not improve severe hematological disorders, but none the less increased 30 days survival in mice up to 100%, versus 50% in the untreated group.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2006
Accession Number
ADA457493

Entities

People

  • A. F. Tsyb
  • L. P. Oulianova
  • R. S. Boudagov

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Bone Marrow Cells
  • Burns
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Diseases And Disorders
  • Leukocytes
  • Lymphatic System
  • Lymphocytes
  • Macrophages
  • Medical Personnel
  • Peptide Growth Factors
  • Proteins
  • Radiation Injuries
  • Stem Cells
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Immunology
  • Immunology and Pathology
  • Microbial Pathology