Chemoprevention of Breast Cancer by Mimicking the Protective Effect of Early First Birth

Abstract

We have successfully identified a set of breast tissue gene expression changes that distinguish parous from nulliparous rats and mice. This is a critical step in our development of a chemoprevention approach to mimic the protective effect of pregnancy in women. These differences are now being studied in women. We have also shown that breast epithelium is overwhelmingly concentrated in mammographically dense areas. This provides a deep insight into the increased risk associated with densities and since densities are reduced by pregnancy, insight into another mechanism by which pregnancy reduces risk. Fresh breast tissue sample collection from normal women is now well underway and the first chemoprevention- associated study has begun recruiting women.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2006
Accession Number
ADA457671

Entities

People

  • Malcolm C Pike

Organizations

  • University of Southern California

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Factors
  • Biomedical Research
  • Blood
  • Carcinoma
  • Carrier Proteins
  • Cells
  • Cellular Structures
  • Chemistry
  • Connective Tissue
  • Drug Therapy
  • Epithelial Cells
  • Gene Expression
  • Institutional Review Board
  • Lymphocytes
  • Medical Personnel
  • Proteins
  • Tissues

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Molecular Biology and Genetics
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology