The Role of the ADAM-15 Disintegrin in E-Cadherin Proteolysis and Prostate Cancer Metastasis
Abstract
Our laboratory has shown that ADAMl5 is predominantly overexpressed in metastatic prostate cancer. Importantly, the chromosomal location of ADAMl5 on 1q21, a region of specific and high-level amplification in metastatic prostate cancer, makes this disintegrin a strong candidate in the malignant progression of this disease. Our preliminary data strongly suggests aberrant function of this protein in the growth, angiogenesis and metastatic progression of prostate cancer. Previous research indicates functional roles of ADAMIS in vascular endothelial biology with clear implications in endothelial interaction and angiogenesis. However, the specific actions of ADAMl5 in tumor epithelium and influences on neighboring endothelial cells in the tumor microenvironment have not been explored. The continuing studies, if successful, will not only confirm the role of ADAMi5 in the malignant processes of prostate tumorigenesis and progression, but will justify future translational studies of ADAMi5 as a direct therapeutic target for this disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2006
- Accession Number
- ADA457694
Entities
People
- Mark L. Day
Organizations
- University of Michigan