Radiation Sensitization in Breast Cancer via Targeting Survivin Expression
Abstract
We proposed to determine whether overexpression of survivin results in radio resistance and the possible mechanisms; whether regulators of survivin serve as targets for radiosensitization. We also found that deregulation of survivin in breast cancer is mediated by Stats (Signal transducer and activator of transcription). Co-inhibition of survivin and State results in significantly increased sensitization of breast cancer. These concepts are being tested in animal models of breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2006
- Accession Number
- ADA457704
Entities
People
- Bo Lu
Organizations
- Vanderbilt University