Theoretical Modeling of Molecular Mechanism, Time Scales, and Strains in Prion Diseases
Abstract
We have obtained significant research results on: 1)modeling the role of oligomeric intermediates in prion disease incubation dynamics and aggregation; 2) using an amino acid specific metal ions in the octarepeat regions of the prion protein, and 4) developing stochastic algorithm models for aggregation processes in prion disease. In the coming year we will: 1) attempt to extend our monte carlo code to allow for beta-sheet interactions between peptides; 2) develop more realistic electronic structure models for metal ions in prion diseases; 3) extend our stochastic kinetics algorithm to the study of strains, first in prion-like proteins for yeast, and 4) explore the possibility of a novel, non-invasive detection scheme based upon observations of metal ions content fluctuations both in vivo and in vitro.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA457967
Entities
People
- Daniel L. Cox
- Rajiv R. Singh
Organizations
- University of California