Chemo Resistance of Breast Cancer Stem Cells

Abstract

This past year was the second year of the DOD award. Over this year we have made substantial progress in achieving the goals outlined in the proposal. In addition, we have found that the enzyme aldehyde dehydrogenase 1 is an excellent marker for cancer stem cells which can be readily detected in fixed histological sections. Development of this new tool will greatly facilitate future studies. Preliminary results both in xenograft models as well as in neoadjuvant trial are providing strong support for our hypothesis for resistance of cancer cells to chemotherapy. We have also made excellent progress at elucidating the pathways which regulate the cells including Hedgehog signaling and Bmi-1. Together these studies provide a rationale for the combination compounds which inhibit stem cell renewal pathways such as Hedgehog with chemotherapeutic agents.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2006
Accession Number
ADA458223

Entities

People

  • Max S. Wicha

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Breast Cancer
  • Cell Division
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Intercellular Junctions
  • Neoplasms
  • Oncology
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Stem Cells
  • Three Dimensional

Readers

  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology