Western Blot Banding Patterns of HIV Rapid Progressors in the U.S. Navy Seropositive Cohort: Implications for Vaccine Development
Abstract
Although human immunodeficiency virus (HIV) infection is progressive, the rate of decline in CD4+ lymphocyte counts varies. The role of the immune system components in limiting HIV infection has yet to be defined, but a previous report in the U.S. Navy HIV Seropositive Cohort reported that strong reactivity in the anti-p55 (core precursor), p24 (core) and p53 (reverse trascriptase) Western blot bands was associated with higher CD4+ lymphoycte counts at the first clinical evaluation for HIV. The previous report examined the cross-sectional association between Western blot banding patterns and initial CD+4 lymphocyte counts. This report examines the association between these banding patterns in individuals who progressed rapidly as compared with patterns of patients who did not, based on their trends in repeated CD+4 lymphocyte counts as a marker of progression. Rapid and slower progressors were identified from a cohort of 3414 Navy and Marine Corp personnel who had a first positive HIV Western blot during 1986-1991. For purposes of this study, rapid progressors were defined as individuals whose CD+4 lymphocyte counts declined to < 500 cells/cubic mm within 1 year of seroconversion.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 18, 1996
- Accession Number
- ADA458697
Entities
People
- Cedric F. Garland
- Edward Doerr Gorham
- Frank C. Garland
- Stephanie K. Brodine
Organizations
- Naval Health Research Center