Toward High Magnetic Moment, Controlled-Size, Blood Dispersible Nanoparticles: An Enabling Technology for Biomagnetics Interfacing Concepts
Abstract
We have developed a productive alliance with Drs. Kaminski and Mertz from the Argonne National Laboratories and with Dr. Rosengart from the University of Chicago, who have designed a unique, portable, blood detoxification device with the goal of magnetically filtering undesirable components from the blood stream. Our group has supported their DARPA-AFOSR project entitled Biohazard Detoxification Method Utilizing Magnetic Particles by providing materials and materials guidance. Our focus during the current year has been on achieving biodegradable nanospheres in the 100-500 nm diameter size range which contain high concentrations of magnetite. The current status of this work is that we have poly(D,L-lactide) nanospheres which contain 40 weight percent magnetite. The average nanosphere diameter is approximately 80-90 nm. We have incorporated one weight percent of a 2k-20k Mn poly(ethylene oxide-b-D,L-lactide) block copolymer into the nanospheres in efforts to achieve hydrophilic surfaces. The current focus is on (1) learning how to increase the nanosphere size slightly to achieve 100-500 nm particles, (2) achieving even higher concentrations of magnetite, and (3) understanding how to achieve surfaces sufficiently covered with poly(ethylene oxide) with this nanosphere process to avoid immune response. We will collaborate with Kaminski/Mertz/Rosengart to relate nanosphere composition and processing to immune response.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 02, 2006
- Accession Number
- ADA458869
Entities
People
- Judy S Riffle
Organizations
- Virginia Tech