Caveolin-1 Modulates Androgen Receptor Signaling in Advanced Prostate Cancer

Abstract

In the past funding year, we characterized a novel serinelthreonine p21 activated protein kinase 6 (PAK6) as a key signal mediator in regulating non-genomic AR signal transduction within membrane-associated caveoliniraft domain. We found that in prostate cancer cells androgen stimulation activates PAK6. Consequently, PAK6 activation promotes prostate cancer cell motility. Ectopic expression of constitutive active PAK6 in prostate cancer LNCap cells promotes ancharage-independent soft agar colony growth. Our results support the hypothesis set fort from our original proposal that AR signaling from raft to regulate its non-genomic function

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2006
Accession Number
ADA459172

Entities

People

  • Michael L. Lu

Organizations

  • Brigham and Women's Hospital

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Cell Line
  • Cell Membrane
  • Cell Membrane Structures
  • Cell Movement
  • Cell Physiological Processes
  • Cell Physiology
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Epithelial Cells
  • Growth Factors
  • Health Services
  • Neoplasms
  • Prostate Cancer
  • Proteins

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Prostate Cancer Biology.