Temporal and Spatial Dynamics of DNA Topoisomerase 1 in Prostate Cancer

Abstract

The purpose of this proposal was to investigate the response of prostate cancer to a series of camptothecin analogs, which are drugs that target DNA topoisomerase I. This final report summarizes the accomplishments toward the original goals of the project. We note that while some experimental problems were encountered that limited the completion of all tasks, good progress was made overall on the proposed research.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2006
Accession Number
ADA459174

Entities

People

  • Randy M. Wadkins

Organizations

  • University of Mississippi

Tags

DTIC Thesaurus Topics

  • Alkaloids
  • Apoptosis
  • Biomedical Research
  • Cell Line
  • Cells
  • Chemical Compounds
  • Chemistry
  • Dynamics
  • Epithelial Cells
  • Health Services
  • Hydrophilic Properties
  • Hydrophobic Properties
  • Medical Personnel
  • Neoplasms
  • Physical Properties
  • Prostate
  • Prostate Cancer

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Oncology (Cancer Research).
  • Technical Research and Report Writing.