Generation of Advanced Diagnostics and Countermeasures for Individuals Most Vulnerable to Biothreats
Abstract
In the first phase of this proposal, we identified mouse strains differentially resistant and susceptible to infection with three biothreat pathogens, Cowpox, Influenza, and Anthrax. In the second phase, the scope of our project is to identify: 1. Host-Oriented Pathogen Response (HOPR) Signaling Pathways, as the underlying mechanism responsible for host-specific susceptibility; and 2. the specific protein constellations responsible for the resistant or susceptible phenotypes. Pinpointing the specific protein(s) responsible for the host responses will allow us to develop specific drugs to convert susceptible into resistant phenotypes. Out ultimate goal is to use the knowledge and enabling technology gained for advanced diagnosis and countermeasures to biothreats.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2006
- Accession Number
- ADA459331
Entities
People
- Eugenia Wang
Organizations
- University of Louisville