Neural Protein Synuclein (SNCG) in Breast Cancer Progression

Abstract

Synucleins are emerging as central players in the formation of pathologically insoluble deposits characteristic of neurodegenerative diseases. However, synuclein-gamma (SNCG), previously identified as a breast cancer specific gene (BCSG1), is also highly associated with breast cancer progression. Using transgenic mouse model, we demonstrated a role of SNCG in induction of highly proliferative pregnancy-like phenotype of mammary epithelial cells, branching morphology, and mammary hyperplasia. SNCG participated in the heat shock protein-based multiprotein chaperone complex for steroid receptor signaling. Expression of SNCG in mammary epithelium resulted in a significant stimulation of ERalpha transcriptional activity. SNCG-induced mammary hyperplasia can be effectively blocked by antiestrogen and ovariectomy, indicating that the induced hyperplasia is mediated by ERalpha signaling and requires estrogen stimulation. These data indicate the chaperone activity of SNCG on stimulation of steroid receptor signaling in mammary gland and, thus induces mammary hyperplasia and contributes to the hormonal impact on mammary tumorigenesis.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2005
Accession Number
ADA459728

Entities

People

  • Yangfu Jiang

Organizations

  • Long Island Jewish Medical Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Department Of Defense
  • Electronic Mail
  • Epithelial Cells
  • Hyperplasia
  • Information Operations
  • Mammary Glands
  • Neoplasms
  • Neurodegenerative Diseases
  • New York

Fields of Study

  • Biology

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