Fully Virulent Bacillus Anthracis Does Not Require the Immunodominant Protein BclA for Pathogenesis

Abstract

The BclA protein is the immunodominant epitope on the surface of Bacillus anthracis spores; however, its roles in pathogenesis are unclear. We constructed a BclA deletion mutant (bclA) of the fully virulent Ames strain. This derivative retained full virulence in several small animal models of infection despite the bclA deletion.

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Document Details

Document Type
Technical Report
Publication Date
Oct 20, 2006
Accession Number
ADA460050

Entities

People

  • C. K. Cote
  • J. Bozue
  • L. Moody
  • S. L. Welkos

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Bacteria
  • Bacteriology
  • Biomedical Research
  • Cells
  • Diseases And Disorders
  • Germination
  • Immunity
  • Infection
  • Laboratory Animals
  • Microbiology
  • Pathogenesis
  • Proteins
  • Rodents
  • Standards
  • Virulence
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Immunology
  • Military/Explosive Ordnance Disposal (EOD) Technology