Prostate Derived Ets Factor, an Immunogenic Breast Cancer Antigen
Abstract
The goal of the proposed research was to test the following concept. Due to prostate restricted expression of Pse in normal tissues of mice, Pse is likely to be immunogenic in female mice. T cell responses of male and female mice to Pse and a control antigen Her-2/neu were compared. Two different assays were used for this purpose; the ELISPOT assay and the Cytotoxicity assay. To date, we have found that in the FVB strain of mice immunization with Pse induces specific T cell responses in female mice but not in male mice. In contrast, Her-2/neu is immunogenic in both female and male mice. These results are novel and significant and they support our concept and suggest that PDEF (the human homologue of Pse) is likely to be similarly immunogenic in female breast cancer patients. Our results also suggest that lack of immunogenicity of Pse in male mice is likely due to some mechanism of tolerance to a self protein since Pse/PDEF is strongly expressed in the normal prostate tissue of males.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2006
- Accession Number
- ADA460073
Entities
People
- Ashwani Sood
Organizations
- Health Research, Incorporated