Non-Invasive Markers of Tumor Growth, Metastases and Sensitivity to AntiNeoplastic Therapy

Abstract

The goals of this application are to develop methods to non-invasively differentiate fast and slow growing prostate tumors and also develop methods to evaluate response to anti-angiogenic agents. Validation of the results will be based on tumor growth, metastases, and microvessel density measurement (anti-angiogenic studies). To date, we have focused on optimizing the pulse sequences necessary for lactate detection, synthesizing a macromolecular contrast agent and optimizing its use. These goals have been more difficult to achieve but we are now able to localize lactate within an image plane of the tumor and have finished synthesizing the macromolecular contrast agent and optimizing its use.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2006
Accession Number
ADA460278

Entities

People

  • Jason A Koutcher

Organizations

  • Memorial Sloan Kettering Cancer Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Anatomy
  • Biological Sciences
  • Biomedical Research
  • Chemical Shifts
  • Contrast
  • Department Of Defense
  • Detection
  • Electronic Mail
  • Geometry
  • Information Operations
  • Magnetic Resonance
  • New York
  • Prostate
  • Resonance
  • Sequences
  • Spectra

Readers

  • Medical Imaging.
  • Oncology (Cancer Research).