Soy and Tamoxifen for Breast Cancer Prevention in High Risk Pre-Menopausal Women
Abstract
We conducted a feasibility study to assess the efficacy and safety of dietary soy for breast cancer prevention in pre-menopausal women at elevated risk of breast cancer. Mammographic breast density, a potential surrogate marker for breast cancer risk, was used as the primary entry criterion and the primary outcome. 47 pre-menopausal women with breast density ! 50% on mammography were randomized to either 25 mgld of soy protein containing 50 mg total isoflavones or 25 mglday of milk protein containing 0 mg of total isoflavones for 6 months. At randomization, the average 5-year Gail risk was 2.0% and the average breast density was 73% (range 59%-90%). The average change in percentage breast density was -2.7% in the soy arm and -2.4% in the placebo arm (p=O.48). There were no differences between groups in the change in lGF-I or lGFBP3. The results of this study do not support the hypothesis that 6 months of soy protein reduces the risk of breast cancer in pre-menopausal women. However, the intervention was relatively short and the primary outcomes were surrogate markers of risk.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2005
- Accession Number
- ADA460295
Entities
People
- Jeffrey A. Tice
Organizations
- University of California, San Francisco