Effects of Androgen Blockade on Cognitive Function and Quality of Life in Men with Prostate Cancer
Abstract
The purpose of this project was to examine the nature and severity of cognitive impairments experienced by men undergoing continuous androgen deprivation or intermittent androgen deprivation treatment (ADT). The cognitive abilities of androgen deprivation patients were compared with those of a sample of healthy men. We undertook collection of data from 40 men on intermittent or continuous ADT and an age- and education-matched sample of 34 control subjects. Our major hypothesis was that patients undergoing ADT will experience impairments in those cognitive abilities reported in the research literature to be related to androgen levels (e.g. spatial ability working memory for visual information). Bureaucratic requirements (largely related to institutional research board and General Clinical Research Center reviews) delayed the start of the project by nearly 20 months necessitating two no-cost extensions. Data collection is complete and the data have been entered into a database. Because analysis of the data is only now getting underway there are as yet no results to report. We anticipate that data analysis will be completed during the fall of 2006 with at least one paper on the primary findings submitted for publication by the end of the calendar year.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2006
- Accession Number
- ADA460464
Entities
People
- Angela G. Brega
- James P. Grigsby
Organizations
- University of Colorado Health