Estrogen Metabolism and Prostate Cancer Risk: A Prospective Study
Abstract
Prostate cancer is the most common cancer among men in the United States and the second most common in the European Community. The causes of prostate cancer, however, remain largely unknown, with age, race, and family history being the only established risk factors. The prostate gland has historically been considered the prototype of an androgen-dependent organ. However, there is evidence that estrogens may induce mitosis of prostatic epithelial cells in many species, including humans. This report analyzes the association between prostate cancer and estrogen metabolism in a case-control study. In particular, the authors tested the hypothesis that the pathway favoring 2-hydroxylation over 16alpha-hydroxylation may be associated with a decrease in prostate cancer risk. This is the annual report for the third year of the study. During the third year of activity, the authors completed the definition of the large data set of the study, conducted quality control procedures on the collected data, and developed new laboratory procedures for the determination of the estrogen metabolites using gas-chromatography. The hormone determinations are now in an advanced phase of progress.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2006
- Accession Number
- ADA460477
Entities
People
- Paola Muti