DNA Conforming Dynamics and Protein Binding

Abstract

Recent advances in single%molecule force spectroscopy of DNA make it possible to study the thermodynamics and kinetics of DNA binding proteins under a wide range of conditions. A biophysical model for the DNA binding T4 gene 32 protein has been developed to study the kinetics of DNA protein binding to transient single-stranded DNA regions due to thermal fluctuations. The model is used to analyze recent single-molecule spectroscopy data of this system.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2006
Accession Number
ADA461014

Entities

People

  • Andreas Hanke

Organizations

  • University of Texas at Brownsville

Tags

Communities of Interest

  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Abstracts
  • Carrier Proteins
  • Chemistry
  • Dynamics
  • Energy
  • Equations
  • Free Energy
  • Hydrogen Bonds
  • Kinetics
  • Low Density
  • Macromolecules
  • Molecules
  • Optical Tweezers
  • Physics
  • Proteins
  • Spectroscopy
  • Thermodynamics

Fields of Study

  • Biology
  • Chemistry
  • Physics

Readers

  • Computational Modeling and Simulation
  • Molecular Genetics
  • Nanoscale Plasmonic Nanotechnology

Technology Areas

  • Biotechnology