Biomarkers of Selenium Action in Prostate Cancer

Abstract

This study was designed to identify new, mechanistically relevant biomarkers of selenium responsiveness for use in intervention trials. We have characterized the global transcriptional response of LNCaP prostate cancer cells to selenium by using cDNA microarray. We have identified molecular targets of selenium that are secretory using bioinformatics approaches and datasets of selenium modulated transcripts and membrane bound and secretory proteins. To help prioritizing biomarker candidates, we have cross-referenced the selenium modulated genes list with existing prostate cancer microarray data sets. Using this approach, we have narrowed down the number of biomarker candidates that we are now characterizing in more details.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2006
Accession Number
ADA461946

Entities

People

  • Jacques Lapointe

Organizations

  • Stanford University

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Biological Sciences
  • Blood
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Techniques
  • Dna Microarrays
  • Gene Expression
  • Genetics
  • Microarray Analysis
  • Neoplasms
  • Organoselenium Compounds
  • Prostate Cancer
  • Proteins
  • Tumor Cell Line

Readers

  • Molecular Genetics
  • Prostate Cancer Biology.