Optical Strategies for Studying Metastatic Mechanisms, Tumor Cell Detection and Treatment of Prostate Cancer

Abstract

Prostate cancer is the most common cancer in men. Current treatments have limitations due to undesirable side effects. The objective of this proposal is to evaluate the effect of photodynamic therapy (PDT) on prostate tumors in order to design optimal treatment regimens. We have shown that subcurative PDT induces the release of the Vascular Endothelial Growth Factor (VEGF) both in vitro and in an orthotopic model of prostate cancer. Furthermore, we report that combining PDT with an antiangiogenic molecule, to prevent the action of VEGF,improves local control of prostate cancer and reduces the incidence of metastasis. Using a highly aggressive and metastatic prostate cancer cell line, we also report a PDT-induced decrease in 1 integrin coinciding with a decrease in adhesion to the extracellular matrix protein, collagen IV. Finally experimental metastasis assay showed that PDT-treated cells circulate longer in animals than control cells. We conclude that the most effective application of PDT for long-term cure, may involve combined therapeutic regimens.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2006
Accession Number
ADA462383

Entities

People

  • Nicolas Solban

Organizations

  • Massachusetts General Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Body Weight
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Diseases And Disorders
  • Gene Expression
  • Growth Factors
  • Health Services
  • Laser Therapy
  • Molecules
  • Neoplasms
  • Prostate Cancer
  • Proteins

Fields of Study

  • Medicine

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology (Cancer Research).