Simultaneous Monitoring of Vascular Oxygenation and Tissue Oxygen Tension of Breast Tumors under Hyperbaric Oxygen Exposure
Abstract
The goals of the study in the second stage is to investigate vascular oxygenation and tissue oxygen tension of breast tumor under four different hyperbaric oxygen exposures, using near-infrared spectroscopy and FOXY oxygen sensor simultaneously. Hyperbaric oxygenation results in a significant increase in the tumor oxygenation and has superior effect than normobaric oxygen in all seventeen tumors. The improvement of tumor oxygenation could be maintained for 10 to 20 minutes after the end of the hyperbaric oxygen exposure. Multiple correlations were examined between magnitudes of vascular ( [HbO2]) and tissue (pO2) responses. Significant correlations were found between responses to normobaric oxygen/carbogen breathing using either modality, but not for responses to hyperbaric oxygen/carbogen. Vascular (R2=0.78) and tissue oxygenation (R2=0.65) also showed the correlations between responses to normobaric and hyperbaric oxygen/carbogen intervention. 15.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2006
- Accession Number
- ADA462386
Entities
People
- Mengna Xia
Organizations
- University of Texas at Dallas