Identification of Novel Retinoid Targets in Prostate Cancer
Abstract
Retinoids have shown promises for the chemoprevention and treatment of cancer. However, except for the efficient treatment of acute promyelocytic leukemia by all-trans retinoic acid, most natural and synthetic retinoids have failed in clinical trials because of toxicity and limited activity. Novel synthetic retinoid-related molecules represent promising leads for the chemoprevention and treatment of prostate cancer. Our goal is to understand the mechanism of action of these analogs at the molecular level, which seems to be independent of the nuclear retinoid receptors. Using a Genetic Suppressor Elements selection approach we aim to identify genes that mediate retinoid function. We have established the experimental conditions to infect PC3 cells with retroviruses expressing a GSE library, which will be used to select cells that survive a killing dose of two synthetic retinoids.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2005
- Accession Number
- ADA462421
Entities
People
- Javier Piedrafita