A New Concept for Androgen Receptor-Independent Growth of Prostate Cancer
Abstract
Angiogenin is an angiogenic ribonuclease that is upregulated in prostate cancer. The objective of this project is to explore the role angiogenin plays in the development of androgen-independent disease. The hypothesis to be tested is that angiogenin plays an essential role in rRNA transcription in prostate cancer cells and that constitutive nuclear translocation of angiogenin is a driving force for transition to androgen independence. Toward this goal, we have carried out experiments to show that overexpression of angiogenin in androgen-dependent LNCaP prostate cancer cells enable them to grow in the absence of androgen, and that knocking-down angiogenin expression in androgen-independent PC-3 prostate cancer cells inhibits cell proliferation in vitro and in vivo, accompanied with a decrease in both cancer cell proliferation and angiogenesis. These results are consistent with our hypothesis and indicate that angiogenin is a novel therapeutic target for prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2006
- Accession Number
- ADA462435
Entities
People
- Guo-fu Hu
- Hiroko Kishikawa
- Norie Yoshioka
Organizations
- Harvard Medical School