Identification and Characterization of Prostate Cancer Associated Protein Biomarkers Using High-Throughput Mass Spectrometry
Abstract
Prostate cancer (PCa) remains to be the most common non-skin cancer in the US. Currently available screening tests for PCa including prostate specific antigen (PSA) test, digital rectal examination (DRE) and prostate biopsy, call for more accurate and non-invasive techniques to detect, diagnose, and stratify the disease based on molecular markers present in the body fluids. There has been an impressive emergence of mass spectrometry based technologies applied toward the study of such biomolecular markers of disease states. Our focus on utilization of such techniques towards prostate cancer will promise a better health and future for PCa patients. We have devised strategies to isolate and identify protein biomarkers from PCa patients in the clinical gray-area where PSA fails to detect cancer. Identification of such cancer biomarkers will assist in development of better non-invasive diagnostic tools for prostate cancer and may also lead to better therapeutic targets.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2006
- Accession Number
- ADA462488
Entities
People
- Gunjan Malik
Organizations
- Eastern Virginia Medical School