In Vivo Molecular Imaging of Mammary Tumorigenesis in Murine Model Systems
Abstract
The development of accurate diagnostic tools and effective breast cancer treatments requires the ability to detect the presence of pre-cancerous, cancerous, and metastatic tissue and to identify the particular subtype or class of tumor. It is equally imperative to develop the capability of performing a molecular diagnosis non-invasively, employing in vivo imaging technologies in order to follow the tumor progression over time. This project entails an interdisciplinary approach which employs a gamma-ray-camera detector system to follow, during tumorigenesis, the uptake of NaI through the Na+/I- symporter, and the binding characteristics and localization of vascular endothelial growth factor, epidermal growth factor, and estradiol in mouse models of breast cancer. Using the MMTV model for mammary tumor development, we have found that I- 125 labeled sodium iodide provides a valuable tag for imaging mammary tumors at several different stages of their development. Moreover, it is also able to provide an image of the heterogeneity among tumors and within a given tumor, making it potentially useful as a strategy for non-invasively imaging and classifying mammary tumors for purposes of prognosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2006
- Accession Number
- ADA462553
Entities
People
- Margaret S. Saha
Organizations
- College of William & Mary