Fluorescence and Diffuse Reflectance Spectroscopy for Breast Cancer Diagnosis During Core Needle Biopsy
Abstract
The goal of this project is to exploit the potential of using fluorescence and diffuse reflectance spectroscopy for breast cancer detection during a core needle breast biopsy. A novel side-firing fiber optic probe has been developed for use in a vacuum-assisted core biopsy needle. The probe design has been evaluated using tissue phantom studies before embarking on the clinical study and proved to be capable of making fluorescence measurements with good signal-to-noise ratio. Clinical trials have been carried out to use the optical probe for in vivo fluorescence spectroscopy of breast tissues during a core needle breast biopsy to determine the feasibility of using this technique for a near real time discrimination between malignant and benign breast tissues. Preliminary results showed that in vivo fluorescence spectroscopy during a percutaneous breast biopsy is feasible and has the potential to quickly characterize tissue composition and pathology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2006
- Accession Number
- ADA462562
Entities
People
- Changfang Zhu
Organizations
- University of Wisconsin–Madison