Tissue Microarray Assessment of Novel Prostate Cancer Biomarkers AMACR and EZH2 and Immunologic Response to them in African-American and Caucasian Men

Abstract

Prostate cancer is a leading cause of cancer-related death in American men. Prostate cancer like other cancers is characterized by complex molecular events influenced by diverse genetic and environmental factors. The objective of the present study was to compare the expression of AMACR and EZH2 in African-American patients and Caucasian patients with prostate cancer and understand their role. We constructed 5 tissue microarrays representing 40 African-American and 159 Caucasian prostate cancer patients and performed immunohistochemistry on these arrays using antibodies to AMACR and EZH2. Protein expression was scored on these arrays for both AMACR and EZH2. We are presently analyzing the data generated from these experiments and looking into the relative levels of the two markers in prostate cancer patients from the two racial subgroups and also for any associations with survival patterns and clinico-pathologic parameters.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2006
Accession Number
ADA462682

Entities

People

  • Rohit Mehra

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • African Americans
  • Antibodies
  • Bile
  • Biomedical Research
  • Cancer
  • Caucasians
  • Chemical Reactions
  • Detection
  • Diseases And Disorders
  • Ethnic Groups
  • Gene Expression
  • Immunohistochemistry
  • Neoplasms
  • Prostate Cancer
  • Proteins
  • Spreadsheet Software
  • Tissues

Readers

  • Oncology (Cancer Research).
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology