Reaper-Induced Apoptosis

Abstract

Reaper is a central regulator of apoptosis in the fly, Drosophila melanogaster. At the start of this proposal our laboratory identified what was believed to be a pro-apoptotic human homolog of Reaper. This was of extreme interest as no true Reaper homolog had been identified in any organism. Accordingly, we proposed in the original statement of work to investigate the ability of the isolated gene to a) induce apoptosis upon overexpression and b) contribute to radiation induced apoptosis. We then proposed to investigate expression of this protein in response to p53 in breast cancer cells and to monitor control of hrpr production and activity.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2005
Accession Number
ADA462723

Entities

People

  • Jennifer Perry

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cells
  • Department Of Defense
  • Diptera
  • Drosophila
  • Information Operations
  • Inhibition
  • Inhibitors
  • Ionizing Radiation
  • Message Encoding
  • Neoplasms
  • Organelles
  • Radiation
  • Translations

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Research Science/Academic Research