Role of Myelofibrosis in Hematotoxicity of Munition RDX Environmental Degradation Product MNX
Abstract
The purpose of this research is to determine mechanisms through which hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX), environmental degradation product of high energetic munition hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), causes persistent anemia in the rat. We have hypothesized MNX targets hematopoeitic stem cells and, like other myelosuppressive chemicals, will be fibrogenic to the bone marrow. Findings of this period are: 1) additional MNX suppressive effects on peripheral blood cells of myeloid lineage and similar effects of RDX and 2) suppression of bone marrow erythroid and myeloid stem cells of bone marrow by both MNX and RDX. Myeloid development appears more sensitive than erythroid, especially to RDX. These results suggest that MNX- and RDX toxicity in the rat appears to mimic some clinical manifestations of the myeloproliferative disorder, idiopathic myelofibrosis, and thus may offer a model for study of disease progression and intervention strategies. With respect to remediation of RDX-contaminated sites, collectively these data argue that risk of adverse hematological effects from exposure are lessened upon natural remediation to nitro reduced products.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2006
- Accession Number
- ADA462778
Entities
People
- Sharon A. Meyer
Organizations
- University of Louisiana at Monroe