Magnetic Resonance Spectroscopy (MRS) of Prostatic Fluids for Early Detection of Prostate Cancer
Abstract
The prostate gland its tissues and fluids have unique metabolic profiles due to specific physiological functions. In this study proton nuclear magnetic resonance spectroscopy (1H-NMRS) is used to analyze potential metabolic markers of prostate cancer (PCa) in human expressed prostatic secretions (EPS). To date metabolic profiles of EPS from 52 men with PCa and from 26 healthy controls have been analyzed. The metabolites analyzed included citrate spermine myo-inositol lactate alanine phosphocholine glutamine acetate and hydroxybutyrate. Absolute concentrations have been quantified using a novel method developed by our Co-Investigator. The results to date indicate that citrate myo-inositol and spermine are potentially important markers of PCa. Further the absolute concentrations of these metabolites in EPS appear to be independent of age increasing the potential utility of these markers due to elimination of age as a confounding variable. Ongoing activities include the prospective validation of these promising results and analysis to determine if these metabolic markers can distinguish between aggressive tumors and those less aggressive.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2005
- Accession Number
- ADA462810
Entities
People
- E. D. Crawford
Organizations
- University of Colorado Health