Fibroblast Growth Factor Receptor-4 and Prostate Cancer Progression
Abstract
We have found that the FGFR-4 Arg388 allele is strongly associated with the occurrence of prostate cancer and with metastasis and PSA recurrence in men undergoing radical prostatectomy. We will test the role of FGFR-4 in prostate cancer metastasis using autochthonous and orthotopic mouse models of cancer We will also identify changes in gene expression due to the presence of the FGFR-4 Arg388 allele that lead to the metastatic phenotype. To this end we have established and carried out the characterization of trangenic mice with prostatic specific expression of FGFR-4 Arg388 and G1y388; constructed a FGFR-4 siRNA lentivirus and a PC3 and LNCaP siRNA cell lines and identified Ehm2 as an FGFR-4 Arg388 regulated gene and characterized its role in prostate cancer. These key reagents will allow us to evaluate the effects of FGFR-4 on prostate cancer progression in vivo. Further studies of FGFR-4 Arg388 regulated gene expression in prostate cancer tissues are underway.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2006
- Accession Number
- ADA462818
Entities
People
- Michael M. Ittmann
Organizations
- Baylor College of Medicine