JP-8 Jet Fuel: Genotoxic and Cytotoxic Studies in Experimental Animals

Abstract

Genotoxicity is often linked to carcinogenesis. The assessment of the genotoxic potential of any "agent" is important in terms of suggesting its carcinogenic potential. Hence, the evaluation of the genotoxic potential of jet fuels, JP-8 and Jet-A has been proposed in these investigations. The rodent micronucleus (MN) assay, which detects micronuclei, arising from both chromosomal fragments and unequal segregation of chromosomes during cell division has been widely applied as an in vivo assay for detecting genotoxic agents. The assay became a standard test system for genotoxicity evaluations in regulatory agencies in several countries (Sofuni 1993, Kirkland 1993, Auletta et al., 1993, Health Protection Branch Genotoxicity Committee, Canada, 1993).

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Document Details

Document Type
Technical Report
Publication Date
Jan 30, 2007
Accession Number
ADA462916

Entities

People

  • Ivan L. Cameron
  • Vijayalaxmi

Organizations

  • University of Texas Health Science Center at San Antonio

Tags

DTIC Thesaurus Topics

  • Air Force Research Laboratories
  • Animals
  • Blood
  • Body Weight
  • Bone Marrow
  • Bone Marrow Cells
  • Cell Division
  • Cells
  • Environmental Protection
  • Fuels
  • Genotoxicity
  • Intellectual Property
  • Jet Engine Fuels
  • Laboratory Animals
  • Medical Personnel
  • Network Protocols
  • Statistical Analysis

Readers

  • Medical Imaging.
  • Petroleum Engineering
  • Toxicology/Environmental Toxicology