Angiogenesis Research to Improve Therapies for Vascular Leak Syndromes, Intra-Abdominal Adhesions, and Arterial Injuries
Abstract
The three goals of this project are: (i) to discover and develop novel drugs which could prevent or reverse the vascular leak syndrome; (ii) to develop angiogenesis inhibitors which would inhibit post-operative abdominal adhesions; and, (iii) to isolate endothelial progenitor cells from blood, capable of being expanded in vitro and applied to vascular grafts. Progress has been made in each category: we have demonstrated suppression of vascular leak by Caplostatin in response to the pro-angiogenic agent VEGF; we have demonstrated that celebrex has an effect on adhesion prevention, and we have two other angiogenesis inhibitors that we would now like to test; and, we have identified cells from cord blood and adult bone marrow that can substitute for mature smooth muscle cells isolated from a healthy vein.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2007
- Accession Number
- ADA463467
Entities
People
- Joyce Bischoff
- Judah Folkman
- Mark Puder