Immune Cells, if Rendered Insensitive to Transforming Growth Factorbeta, Can Cure Prostate Cancer

Abstract

The objective of the current proposal is to perform immunotherapy to eradicate prostate cancer and at the same time to avoid the development of autoimmune disease. The proposal contains two tasks. The first task is a combination of IL-2 based tumor-reactive T cell adoptive therapy with the TGF-beta based gene therapy for the treatment of mouse prostate cancer. The second task is A tetracycline inducible TGF-beta based gene therapy. At the time of this report, we have completed Task 1 and three papers have been published. (Cancer Research 65:1761-1769, 2005; Prostate 66:235-247, 2006; Molecular Cancer Therapeutics 5:1733-1743, 2006). Currently, we are in the process of to conduct the final phase of the studies described in Task 2.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2007
Accession Number
ADA463756

Entities

People

  • Chung Lee

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Biological Factors
  • Blood
  • Cell Line
  • Cells
  • Chemistry
  • Culture Media
  • Gene Therapy
  • Growth Factors
  • Health Services
  • Lymphatic System
  • Lymphocytes
  • Peptide Growth Factors
  • Peptides
  • Proteins

Fields of Study

  • Medicine

Readers

  • Oncology (Cancer Research).
  • Technical Research and Report Writing.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech