The Influence of Physical Forces on Progenitor Cell Migration, Proliferation and Differentiation in Fracture Repair

Abstract

The goal of this program is to investigate the influence of controlled mechanical stimulation on the behavior of progenitor cells in an effort to develop strategies to significantly enhance the rate and quality of fracture repair in long bones. In support of these goals we will test the global hypothesis that the migration proliferation and differentiation of systemically or locally delivered Mesenchymal Stem Cells is temporarily dependent on local mechanical conditions within the regenerate tissues.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2006
Accession Number
ADA463855

Entities

People

  • Kurt Hankerson
  • Michael Kilbourn
  • Steven A. Goldstein

Organizations

  • University of Michigan

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Animals
  • Biomedical Research
  • Bone Regeneration
  • Cell Movement
  • Cells
  • Connective Tissue
  • Connective Tissue Cells
  • Department Of Defense
  • Electronic Mail
  • Extraction
  • Lasers
  • Materials
  • Migration
  • Stem Cells
  • Test And Evaluation
  • Tissues

Readers

  • Materials Science (Mechanical Engineering).
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology