The Role of c-FLIP(L) in Regulating Apoptotic Pathways in Prostate Cancer

Abstract

Abnormalities in programmed cell death (apoptosis) machinery play a crucial role in initiation progression and metastasis of prostate cancer. Therefore molecules that initiate pro-apoptotic pathways are excellent therapeutic agents in prostate cancer. However some prostate cancer cells develop resistance to pro-apoptotic agents. In this proposal we are examining the regulatory mechanisms of c-FLIP(L) which is an important modular of apoptosis in prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2006
Accession Number
ADA463973

Entities

People

  • Aria F. Olumi

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Chemistry
  • Enzyme Inhibitors
  • Gene Expression
  • Health Services
  • Molecules
  • Neoplasms
  • Programmed Cell Death
  • Prostate Cancer
  • Proteins
  • Tissues
  • Transcription Factors
  • Transfection

Readers

  • Molecular Biology and Genetics