Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography

Abstract

The research carried out during the current reporting period included: (a) Setting up of the near-infrared optical imaging experimental arrangements, (b) Development of an approach for optical tomographic imaging using independent component analysis (OPTICA), (c) Development of a tomographic image reconstruction approach using the "round-trip matrix" approach, and, (d) Target detection and localization using the combined experimental and theoretical approaches. OPTICA is applicable for detection and localization of scattering, absorptive, and fluorescent targets and was demonstrated to provide locations of targets in model media, breast phantoms, and model breasts assembled using ex vivo human breast tissues with millimeter accuracy. The round-trip matrix approach could locate 6 targets embedded in a turbid medium that is 50 transport mean free path thick in simulation. These results have potential applications in obtaining accurate location of tumors within breast, as well as, in lumpectomy.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2006
Accession Number
ADA464218

Entities

People

  • Robert Alfano

Organizations

  • City University of New York

Tags

Communities of Interest

  • Air Platforms
  • Biomedical

DTIC Thesaurus Topics

  • Absorption Coefficients
  • Accuracy
  • Breast Cancer
  • Detection
  • Detectors
  • Diffusion Coefficient
  • Geometry
  • Image Reconstruction
  • Lasers
  • Mean Free Path
  • Optical Properties
  • Optics
  • Scattering
  • Simulations
  • Target Detection
  • Three Dimensional
  • Two Dimensional

Fields of Study

  • Physics

Readers

  • Medical Imaging.
  • Optical Physics and Photonics.
  • Sensor Fusion and Tracking Systems.