Seamless Integration of Detection and Therapy for Breast Cancer using Targeted Engineered Nanoparticles

Abstract

This report summarizes the efforts of our team consisting of researchers from Rice University and M. D. Anderson Cancer Center, in the DoD funded CDMRP award towards the development of an integrated nano particle based imaging and therapy of breast cancer. We have used both gold nano particles (Au-NPs) and gold nanoshells for specifically targeting cancer cells. This has been accomplished in two ways. First by attaching anti-human epidermal growth factor receptor 2 (anti-HER 2) antibodies to gold nanoshells for targeting HER 2 expressing SK-BR3 breast carcinoma cells. The second approach is by building biologically active networks of Au-NP and bacteriophages which can be used as in vivo biological sensors for non invasive optical molecular fingerprinting, and cell targeting agents.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2006
Accession Number
ADA465826

Entities

People

  • Naomi J. Halas

Organizations

  • Rice University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Bacteriophages
  • Biosensors
  • Breast Cancer
  • Chemical Synthesis
  • Chemistry
  • Department Of Defense
  • Detection
  • Detectors
  • Engineering
  • Growth Factors
  • Metallic Nanoparticles
  • Nanotechnology
  • Neoplasms
  • Particles
  • Proteins
  • Surface Plasmon Resonance

Readers

  • Breast cancer cell signaling and growth regulation.
  • Clinical Trial Research.
  • Nanocomposite Materials Science

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech