Activated Ras as a Direct Therapeutic Target for Neurofibromatosis Type 1: An Innovative Approach for Identifying Classes of Inhibitors

Abstract

Neurofibromatosis Type 1 (NF1) arises from the aberrant activation of Ras, a GTPases important controlling mitogenic potential. In an effort to control the aberrant activation of Ras to treat NF1 as well as other cancer, a high throughput screen was developed to screen for small molecule inhibitors of Ras activation by Sos1, a ubiquitous guanine nucleotide exchange factor that catalyzes the activation of Ras. Using this screen, several initial leads have been identified. Future work will define the efficacy and modes of action of these compounds to inhibit Sos1-catalyzed activation of Ras prior to more extensive quantitative structure-activity relationships.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2006
Accession Number
ADA465849

Entities

People

  • John Sondek

Organizations

  • University of North Carolina at Chapel Hill

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cells
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Diseases And Disorders
  • Inhibitors
  • Molecules
  • Neoplasms
  • Nervous System
  • Neurofibromatosis
  • Neuromuscular Diseases
  • Nucleotides
  • Peripheral Nervous System
  • Small Molecules
  • Throughput

Fields of Study

  • Biology
  • Chemistry

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