The Role of Beta-Catenin in Androgen Receptor Signaling
Abstract
Dr. Truica previously showed that the cell adhesion molecule beta-catenin forms a complex with the androgen receptor (AR) and modulate its transcription. The cross talk between beta- catenin and AR signaling can play an important role in AR transcriptional in prostate cancer progression. Our preliminary data seem indicate stromally derived paracrine Wnt family members activate the epithelial frizzled receptor to enable prostate epithelial survival in an androgen deficient environment. We will continue to test the original hypothesis that there is a direct molecular interaction between -catenin and the Cterminus region of AR involved in the mechanism of prostate androgen responsiveness. However, we will examine the repercussions of the interaction in both LNCaP (originally proposed) and primary cultures of mouse prostatic stromal cells. The physiologic response to androgen ablation (castration) differ significantly between the prostatic stroma and epithelia despite the common expression of -catenin and AR, as evidence for the different transcriptional cofactor interactions found in prostatic epithelial and stromal cells. The future work will adhere to the previously approved tasks and those detailed in the body of this report with the additional examination of prostatic stromal cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2005
- Accession Number
- ADA465853
Entities
People
- Neil A. Bhowmick
Organizations
- Vanderbilt University