The Effects of Repeated Low-Dose Sarin Exposure

Abstract

This project assessed the effects of repeated low-dose exposure of guinea pigs to the organophosphorus nerve agent sarin. Animals were injected once a day, 5 days per week (Monday-Friday), for 2 weeks with fractions (0.3 x, 0.4 x, 0.5 x or 0.6 x) of the established LD50 dose of sarin (42 micrograms/kg, s.c.). Animals were assessed for changes in body weight, red blood cell (RBC) acetylcholinesterase (AChE) levels, neurobehavioral reactions to a functional observational battery (FOB), cortical electroencephalographic (EEG) power spectrum, and intrinsic acetylcholine (ACh) neurotransmitter (NT) regulation over the 2 weeks of sarin exposure and for up to 12 days post-injection.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2005
Accession Number
ADA465906

Entities

People

  • John H. McDonough
  • Stanely W. Hulet
  • Tsung-Ming Shih

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Biological Sciences
  • Blood
  • Body Weight
  • Cells
  • Chemical Synthesis
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemical Weapons
  • Chemistry
  • Enzyme Inhibitors
  • Health Services
  • Medical Personnel
  • Nerve Agents
  • Organophosphates
  • Rodents

Fields of Study

  • Biology

Readers

  • Neuroscience
  • Neurotoxicology
  • Toxicology/Environmental Toxicology