Pim Protein Kinase-Levels Correlate with Prostate Tumor Growth and Chemo- Resistance - Potential Mechanism of PIM Action

Abstract

Pim is a protein kinase that has been implicated to play a role in prostate cancer. Kaplan-Meier analysis demonstrated that those patients with high Pim-1 expression are at a significantly greater risk for developing metastatic cancer. In transgenic animal models, the levels of Pim-1 protein kinase are elevated in prostate tumors caused by over expression of the c-myc ongoene, a gene overexpressed in human prostate cancer. In this proposal, we will examine whether Pim mimics Akt and TOR or modulates additional biochemical pathways and use knockout mice to dissect how myc and Pim collaborate to induce transformation and growth or prostate cancers. Pim inhibitors alone or in combination with TOR inhibitors will make a powerful chemotherapeutic strategy.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2006
Accession Number
ADA466143

Entities

People

  • Andrew S Kraft

Organizations

  • Medical University of South Carolina

Tags

DTIC Thesaurus Topics

  • Albumins
  • Amino Acids
  • Anti-Bacterial Agents
  • Biomedical And Dental Materials
  • Blood
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Gene Therapy
  • Genetically Modified Organisms
  • Molecular Biology
  • Neoplasms
  • Oncology
  • Prostate Cancer
  • Proteins
  • Sodium Compounds

Fields of Study

  • Biology

Readers

  • Aerodynamics.
  • Oncology (Cancer Research).