Structural Studies on Toxins and Virulence Factors of Yersinia Pestis

Abstract

In this annual report we present our continuing efforts on two or three fronts. We are working on the expression purification and crystallization of complexes of YopB and YopD with other proteins like their chaperones. We have made progress in purifying YopB:YopD:SycD complex. If successful this will help in understanding the translocation mechanism of effector proteins. Our crystallization efforts on YopH and SycD are continuing.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2006
Accession Number
ADA466156

Entities

People

  • S. Swaminathan

Organizations

  • Brookhaven National Laboratory

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anti-Bacterial Agents
  • Aqueous Solutions
  • Biological Toxins
  • Biomedical Research
  • Cell Membrane
  • Cells
  • Crystallization
  • Department Of Defense
  • Electronic Mail
  • Gel Electrophoresis
  • Immune System
  • Molecular Weight
  • Peptides
  • Proteins
  • Three Dimensional
  • Virulence

Fields of Study

  • Chemistry

Readers

  • Microbial Pathology
  • Molecular and Cellular Biochemistry
  • Technical Research and Report Writing.