Structural Studies on Intact Clostridium botulinum Neurotoxins Complexed with Inhibitors Leading to Drug Design

Abstract

This is the fifth annual report under the no cost extension period. In this period we have completed the BoNT/B light chain (full length) structure and the manuscript is ready for submission. The virtual screening of inhibitors with BoNT/E light chain was reported in the last report and we are continuing on that. Due to lack of personnel our plan to continue the same with BoNT/B and A light chains got stalled. However we have started this work now. The work on the C fragment of BoNT/A will be continued in addition to structures of small molecules with holo BoNT/B.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2007
Accession Number
ADA466176

Entities

People

  • S. Swaminathan

Organizations

  • Brookhaven National Laboratory

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biochemistry
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Clostridium
  • Crystal Structure
  • Crystals
  • Inhibitors
  • Membrane Proteins
  • Molecules
  • Neurotoxins
  • Recognition
  • Small Molecules
  • Three Dimensional
  • Toxins

Readers

  • Clinical Trial Research.
  • Microbial Pathology
  • Molecular and Cellular Biochemistry