Regulation of Apoptosis by AFG3L2, a Potential Oncogene

Abstract

Apoptosis, or programmed cell death, is frequently triggered through the release of cytochrome c from mitochondria. Cytosolic cytochrome c then binds to a cytosolic protein known as Apaf-1, which binds to and activates the cell death protease, caspase 9. Many cancers are resistant to apoptosis induced by chemotherapies. During the course of this work we demonstrated that breast cancer cells, while resistant to release of mitochondrial cytochrome c are actually hypersensitive to cytochrome c, once it is released. Our work provides a unique point of sensitivity that might be exploited for the successful treatment of breast cancers.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2005
Accession Number
ADA466558

Entities

People

  • Zachary Schafer

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Apoptosomes
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemotherapeutic Agents
  • Chemotherapy
  • Cytochromes
  • Epithelial Cells
  • Hypersensitivity
  • Multiprotein Complexes
  • Neoplasms
  • Programmed Cell Death
  • Sensitivity

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Cellular and Molecular Pathways of Apoptosis.