Identification of Sonic Hedgehog-Induced Stromal Factors That Stimulate Prostate Tumor Growth

Abstract

We will determine the mechanism by which Shh signaling accelerates prostate tumor growth, identify Shh targets in prostate tumor stroma, and test the effect of individual target genes on tumor growth. The purpose of the report is to evaluate the first year of research. Sonic hedgehog induces tumor growth by a paracrine mechanism using tumor stroma. Shh signaling independent of Shh ligand in tumor stroma accelerates tumor growth. We have identified potential stromal Shh target genes in xenograft tumors and have begun to evaluate the genes in human prostate cancer. Noggin was identified as a Shhinduced paracrine factors that may drive tumor growth by interfering with BMP signaling. Noggin was overexpressed in tumor stroma. Stromal-derived Noggin does not accelerate tumor growth in the presence or absence of Shh. Future research will continue to identify and evaluate Shh-induced paracrine factors that accelerate prostate tumor growth.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2006
Accession Number
ADA466565

Entities

People

  • Aubie Shaw
  • Wade Bushman

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Culture Media
  • Culture Techniques
  • Endothelial Cells
  • Fibroblasts
  • Muscle Cells
  • Neoplasms
  • Peptide Growth Factors
  • Prostate Cancer
  • Skin Cancer
  • Stem Cells
  • Tissues

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).