Cord Blood Stem Cell Procurement in Minority Donors
Abstract
This progress report summarizes the clinical activity of cord blood procurement and the preliminary analysis of the yield of cord blood cells for the purpose of clinical transplantation. The purpose of collection and procurement of cord blood is for public use and will be accessible to all stem cell transplantation centers worldwide. Cord blood is a readily available source of hematopoietic stem cells. It is more accessible than other sources such as live donors since the cryopreserved cord blood units (CBU) have already been extensively characterized in terms of tissue typing and screening for infectious disease markers. The CBU from minority donors especially African/American is particularly valuable because of the difficulty with finding a matched donor. The CBU allows for less stringent matching; thus CBU is a rapid solution to patients who are in urgent need of stem cell transplantation and have no living donor available. We will now summarize the findings of our efforts to expand the cord blood collection program in an outreach setting with a comprehensive educational program to recruit African/American donors. We are able to demonstrate a significant increase of the CBUs collected with time indicating improvement of access to the African/American donor. This activity may compensate for the poor individual yield of the total nucleated cells in the African/American donor CBU and therefore prove to be a more effective method to build the CBU inventory.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2007
- Accession Number
- ADA466680
Entities
People
- Voravit Ratanatharathorn
Organizations
- Wayne State University