PSA-Based Screening Outcomes, Dietary Heterocyclic Amine Exposure, and Prostate Cancer Risk in African Americans
Abstract
Prostate cancer (PC) is the second leading cause of male U.S. cancer deaths, with African-Americans having the highest rate of PC mortality worldwide. A 5- year prospective NIH-funded clinic-based study investigated whether prostate-specific antigen (PSA) and digital rectal exam (DRE) screening indicators of PC risk in 500 African-American men 50 to 70 years of age who underwent PC screening in Oakland, CA (East Bay San Francisco area), were associated with estimated dietary exposures to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), which forms when meat is overcooked. The DOD-funded study expands that NIH-funded work by adding a new %-free-PSA test for 312 (108 from the NIH-funded study, plus 200 additional) men, results of which will be compared with PSA/ DRE results and PhIP exposures estimated by dietary interviews. For 392 men studied under the NIH protocol, an odds ratio (95% CL) of 32 (3.2, 720) for highly elevated PSA (e20 ng/mL) was observed in the highest 15% vs. the lower 50% of estimated daily PhIP intakes. As of 31-12-06, a total of 220 additional men completed participation using the expanded protocol, for a combined total of 612 men. For 562 of these men studied to date, the corresponding OR was found to be 24 (2.20, 533). This study will help define the potential value of improved screening and dietary/behavioral intervention to reduce PC risk.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2007
- Accession Number
- ADA466696
Entities
People
- Kenneth T. Bogen
Organizations
- University of California